Negative Regulator of IFN Regulatory Small Ubiquitin - Related Modifier E 3 Ligase Tripartite Motif - Containing Protein 28

Negative Regulator of IFN Regulatory Factor 7 Ubiquitin - Related Modifier E 3 Ligase and Tripartite Motif - Containing Protein 28 Is a Small

http://www.jimmunol.org/content/187/9/4754 doi:10.4049/jimmunol.1101704 September 2011; 2011;187;4754-4763; Prepublished online 21 J Immunol Rauscher III, Keiko Ozato and Fanxiu Zhu Qiyi Tang, Tsung-Hsien Chang, Hongzhuang Peng, Frank J. Qiming Liang, Hongying Deng, Xiaojuan Li, Xianfang Wu, Negative Regulator of IFN Regulatory Factor 7 Ubiquitin-Related Modifier E3 Ligase and Tripartite Motif-...

Negative Regulator of IFN Regulatory Small Ubiquitin - Related Modifier E 3 Ligase Tripartite Motif - Containing Protein 28 Is a

Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

IFN regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulator of type I IFN-dependent immune responses. Because excessive responses could harm the host, IRF7 itself is delicately regulated at the transcriptional, translational, and posttranslational levels. Modification of IRF7 by small ubiquitin-related modifiers (S...

Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.

Tripartite motif (TRIM) protein TRIM5 of the primate species restricts replication of HIV and other retroviruses. Whereas primates have a single TRIM5 gene, the corresponding locus in the mouse has expanded during evolution, now containing more than eight related genes. Owing to the complexity of the genomic organization, a mouse homolog of TRIM5 has not been fully studied thus far. In the pres...

Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.

Tripartite-motif 21 (TRIM21) is an E3 ubiquitin ligase that regulates innate immune responses by ubiquitinating IFN regulatory factors (IRFs). TRIM21 is mainly found in hematopoietic cells in which its expression is induced by IFNs during viral. infections and in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome. However, the exact molecular mechanism by w...